TGF-beta2 was not CONCLUSION: This study confirmed our hypothesis that collagen types I, III, TGF-beta1 and TGF-beta3 were up-regulated in biopsy specimens obtained from patients with GMC. Complex interaction of TGF-beta1 with profibrotic function and TGF-beta3 with antifibrotic function may increase synthesis of collagens and thereby significantly contribute to the process of gluteal muscle scarring in Collagen cross-links and early postnatal growth in newborns with intrauterine This study assessed growth and skeletal metabolism in full-term newborns with intrauterine growth retardation (IUGR) and determined the value of the urinary excretion of collagen cross-links in predicting postnatal catch-up growth. We studied 38 newborns (16 females) born at term with a birth weight less than the 10th centile of the reference and a ponderal index ([PI] 100 x weight in g/length in cm3) of 27 +/- 09. The sample was divided into 23 children with proportionate ([P] PI > or = 10th centile of the reference) and 15 with nonproportionate ([NP] PI < 10th centile of the reference) IUGR. The weight, head circumference, length, and knee-heel length of the newborns at days 7, 14, 30, 60, and 90 were measured. The height of 23 of the 38 children was also assessed at 27 +/- 6 months of life. Urinary collagen cross-links were analyzed by high-performance liquid chromatography at day 14 and day 60. Most of the infants (68%) underwent catch-up growth, and the growth performance at 3 months was independent of the proportions at birth. Children who did not show catch-up growth in the first trimester of life failed to normalize in height in the following 2 years. The urinary excretion of pyridinoline (Pyd) was not related to the anthropometric measurements. In P children, urinary excretion of deoxypiridinoline (Dpd) at day 14 significantly correlated with the gain in length during the first 3 months, accounting for 25% of the variance. In NP children, these correlations between urinary Dpd and the gain in length were not significant. The evaluation of urinary Dpd excretion at 2 weeks of age might help to determine the therapeutic regimen in IUGR children. Biosynthesis of prelycopersene pyrophosphate and lycopersene by squalene Qureshi AA, Barnes FJ, Semmler EJ, Porter JW.Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvant.A, Zur Megede J, Polo J, Donnelly J, Ulmer J, Otten GR, Miller CJ, Vajdy M, We have previously shown that rhesus macaques were partially protected against high-dose intravenous challenge with simian-human immunodeficiency virus SHIV(SF162P4) following sequential immunization with alphavirus replicon particles (VRP) of a chimeric recombinant VEE/SIN alphavirus (derived from Venezuelan equine encephalitis virus [VEE] and the Sindbis virus [SIN]) encoding human immunodeficiency virus type 1 HIV-1(SF162) gp140DeltaV2 envelope (Env) and trimeric Env protein in MF59 adjuvant (R. Xu, I. K. Srivastava, C. E. Greer, I. ordinary squalane cleanser , Z. Kraft, L. Kuller, J. M. Polo, S. W. Barnett, and L. Stamatatos, AIDS Res. Hum. Retroviruses 22:1022-1030, 2006). The protection did not require T-cell immune responses directed toward simian immunodeficiency virus (SIV) Gag. the ordinary cleanser extend those findings here to demonstrate antibody-mediated protection against mucosal challenge in macaques using prime-boost regimens incorporating both intramuscular and mucosal routes of delivery. The macaques in the vaccination groups were primed with VRP and then boosted with Env protein in MF59 adjuvant, or they were given VRP intramuscular immunizations alone and then challenged with SHIV(SF162P4) (intrarectal challenge). The results demonstrated that these vaccines were able to effectively protect the macaques to different degrees against subsequent mucosal SHIV challenge, but most noteworthy, all macaques that received the intramuscular VRP prime plus Env protein boost were completely protected. A statistically significant association was observed between the titer of virus neutralizing and binding antibodies as well as the avidity of anti-Env antibodies measured prechallenge and protection from infection. These results highlight the merit of the alphavirus replicon vector prime plus Env protein boost vaccine approach for the induction of protective antibody responses and are of particular relevance to advancing our understanding of the potential correlates of immune protection against HIV infection at a relevant mucosal portal of entry.Novel collagen glomerulopathy in a homotrimeric type I collagen mouse (oim).BACKGROUND: Oim/oim mice [osteogenesis imperfecta model; homozygous null for the proalpha2(I) collagen gene] synthesize exclusively the homotrimeric type I collagen isotype, alpha1(I)3, and are unable to synthesize the normal heterotrimeric type I collagen isotype, alpha1(I)2alpha2(I).
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